This thesis described the additional value of bone scintigraphy with [99mTc]Tcoxidronate including Single Photon Emission Computed Tomography / Computed Tomography (bone-SPECT/CT) and of positron emission tomography with integrated computed tomography using sodium fluoride-18 (Na[18F]F-PET/CT) in patients with selected benign bone and joint disease, aiming to improve patient management. Specific subjects of investigation included patients with post-operative painful knees, wrists and hands, peri-operative tarsal coalitions, and patients with fibrous dysplasia before and after treatment.