Bone scintigraphy is a fundamental technique in skeletal imaging within nuclear medicine, especially in rheumatology and orthopaedics. The late phase acquisition offers valuable functional insights into bone remodelling, while the early-phase acquisitions (vascular and blood pool phases) provide information on local blood flow (1). Over time, the acquisition protocol for bone scintigraphy has evolved significantly, marked by two major advancements: the gradual abandon of vascular phase acquisition for most indications and the introduction of Single Photon Emission Computed Tomography/Computed Tomography (SPECT/CT) (2). While it is widely recognised that SPECT/CT outperforms planar acquisition in the late phase (1), there is still a scarcity of research on blood pool SPECT, with only a limited number of studies available (3-7). Accurate assessment of inflammatory processes adds significant value to the diagnosis, especially as the pain often caused by inflammation can be a common indication for bone scans, especially in the lower limbs. This article aims to illustrate the usefulness of blood pool SPECT in the daily practice.